On April 22th in Leukemia journal an article has been published: Anti-oxidant vitamin E Prevents accumulation of imatinibresistant BCR-ABL1 kinase mutations in CML-CP NSG xenografts in mice. The results of the pilot study focused on the potential role of vitamin E as an antioxidant with ability of preventing mutations in the evolution of chronic myeloid leukemia (CML). The experiments were performed on a mouse model, using cells derived from patients in chronic phase CML.
The obtained results shows potential way how the proposed method can prevent formation of a mutation in the treatment of leukemia, and consequently prevent from drug resistance. The work was the result of multi-center study involving scientists from Temple University, Philadelphia, USA; Universitaetsklinikum Jena, Germany; Center for Postgraduate Medical Education, Warsaw and the Medical University of Warsaw. Study was coordinated by Tomasz Skorski.
Leukemia journal is part of the Nature group. Impact Factor is 10,164.
The authors of the paper: Małgorzata Nieborowska-Skorska, Grażyna Hoser, Andreas Hochhaus, Tomasz Stokłosa and Tomasz Skorski.